Effect of blockade of mother to child transmission of hepatitis B on pregnant women with hepatitis B and its effect on exclusive breastfeeding rate and hepatitis B virus load
10.3760/cma.j.cn112866-20200630-00200
- VernacularTitle:母婴阻断在乙型肝炎孕妇中的应用效果及对纯母乳喂养率和乙肝病毒载量的影响
- Author:
Dongmei XU
1
;
Yan XU
;
Huaying CUI
Author Information
1. 东营市东营区人民医院妇产科 257000
- Keywords:
Blockade of mother to child transmission;
Hepatitis B;
Exclusive breastfeeding rate;
Virus load;
Adverse reactions
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(6):640-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of blockade of mother-to-child transmission of hepatitis B virus (HBV) in pregnant women with HBV and its influence on exclusive breastfeeding rate and HBV load.Methods:A total of 82 pregnant women with hepatitis B infection who were treated from March 2015 to March 2018 in Dongying District People’s Hospital of Dongying city were enrolled. They were randomly divided into control group and observation group with 41 cases in each. The control group received telbivudine treatment for blokcade. The observation group received telbivudine combined with lamivudine blockade therapy. The rate of exclusive breastfeeding, the rate of hepatitis B infection, the rate of good response, and the hepatitis B viral load before and after the blockade were compared between the two groups of pregnant women.Results:The rate of exclusive breastfeeding of pregnant women in the observation group was higher than that of the control group ( χ2=8.467, P=0.031), and the rate of HBsAg conversion, the chronicity rate of HBV infection and the positive rate of HBV-DNA were lower than those of the control group ( χ2=8.467, P=0.031). χ2=7.943, 6.581, 5.387, P=0.036, 0.039, 0.041), the result of HBV-DNA viral load, HBsAg and HBeAg quantitative determinations of pregnant women in the observation group after blocking were lower than those in the control group ( t=8.646, 5.491, 9.667, P=0.000); The incidence of nausea, vomiting, diarrhea, rash, premature birth and low birth weight infants in the observation group was lower than those in the control group ( χ2=8.654, P=0.041). Conclusions:Telbivudine combined with lamivudine block can effectively reduce the rate of hepatitis B virus transmission from mothers to their infants, hepatitis B virus load and the incidence of adverse reactions in newborns.
