Clinical application and rethinking of rabies immunoglobulin
10.3760/cma.j.cn112866-20200330-00100
- VernacularTitle:狂犬病免疫球蛋白临床应用及再思考
- Author:
Xuefei WANG
1
;
Fen YANG
;
Ruifeng CHEN
;
Lisong HUANG
;
Yiqing JIA
;
Juan NIU
;
Fei LI
;
Yi SHAN
Author Information
1. 解放军总医院第六医学中心急诊科，北京 100048
- Keywords:
Rabies;
Exposure;
Rabies immunoglobulin (RIG)
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(5):506-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the administration of rabies immunoglobulin (RIG) in populations who had rabies virus exposure, and to investigate the safety of RIG and related factors affecting its administration.Methods:This cross-sectional study included the rabies virus exposed victims who were treated at the sixth medical center of the People’s Liberation Army (PLA) General Hospital from April to November 2019. The clinical characteristics of the patients who accepted RIG injection and those who refused RIG were analyzed and compared, and the determinant factors of the RIG injection were studied by stepwise multiple logistic regression analysis.Results:There were 1 395 cases of category III exposure, of whom 662 (47%) were males, 733 (52.5%) were females. The median age was 29 (9-49) years. Among them, 1 049 cases were injected with RIG, while 346 were not injected with RIG. Side effects associated with RIG injection included pain (97.6%), dizziness (7.0%), nausea (6.5%), chest tightness (2.1%), and syncope (0.3%). Stepwise multiple logistic regression analysis showed that adults ( OR=17.14, 95% CI: 9.69-30.32), middle-aged and elderly ( OR=12.92, 95% CI: 6.83-24.43), and those whose injury was caused by cats ( OR=3.18, 95% CI: 2.09-4.84), scratches ( OR=7.66, 95% CI: 4.27-13.75), those with minor injuries ( OR=21.75, 95% CI: 11.70-40.42) more likely to choose not to inject RIG. Conclusions:It is safe and effective to inject RIG for patients with grade III exposure to rabies virus. Exposed persons who are not injured by dogs, slightly injured and elderly people tend not to inject RIG.
