Serum cytokines and chemokines in patients with severe fever with thrombocytopenia syndrome
10.3760/cma.j.cn112866-20190828-00132
- VernacularTitle:发热伴血小板减少综合征患者血清细胞因子与趋化因子特点分析
- Author:
Hong ZHAO
1
;
Guoliang YANG
;
Ying HAN
;
Xiuyun HAN
;
Yan LYU
;
Xiaoman DING
;
Jing PAN
;
Lanzheng LIU
Author Information
1. 济南市疾病预防控制中心病毒性疾病检验所 250021
- Keywords:
Severe fever with thrombocytopenia syndrome;
Bunyavirus;
Cytokines;
Chemokines
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(5):537-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Serum cytokines and chemokines in patients with fever with thrombocytopenia syndrome (SFTS) and the severity of the disease was studied.Methods:Serum of 47 SFTS patients from 2014 to 2017 in Jinan city was collected. Serum of 11 dead patients and 36 survivors were selected as the survival group and serum of 10 healthy people was selected as the control group. Luminex liquid phase chip was used to detect and analyze the expression levels of 40 cytokines and chemokines in peripheral blood.Results:The expression levels of 27 cytokines and chemokines in the death group were significantly higher than those in the control group ( P<0.05). The expression level of 33 cytokines and chemokines in the death group was significantly higher than that in the survival group ( P<0.05). The expression level of 12 cytokines and chemokines in the survival group was significantly higher than that in the control group ( P<0.05). The expression levels of 10 cytokines and chemokines in the patients were increased in different degrees during the recovery period compared with the acute period ( P<0.05). The expression levels of 5 cytokines and chemokines were lower in the recovery period than in the acute period ( P<0.05). Receiver operating characteristic curve (ROC curve) analysis showed that 22 factors were statistically significant and could be used as biomarkers to predict the severity of the disease. Conclusions:The expression levels of various cytokines and chemokines in serum of SFTS patients changed significantly during the development of the disease and the cytokine storm caused by SFTS may be the cause of death.
