Variation of CD4 +/CD8 + ratio and related influencing factors of HIV/AIDS after receiving antiretroviral treatment in Shandong province
10.3760/cma.j.cn112866-20200519-00168
- VernacularTitle:山东省557例HIV/AIDS抗病毒治疗后CD4 ＋/CD8 ＋比值变化及相关因素分析
- Author:
Jinhai LI
1
;
Na ZHANG
;
Bin LIN
;
Xiaoguang SUN
;
Haiying YU
;
Shengli SU
;
Tao HUANG
;
Xiaoyan ZHU
;
Lei HAN
;
Guoyong WANG
;
Dianmin KANG
Author Information
1. 山东省疾病预防控制中心，济南 250014
- Keywords:
AIDS;
Highly active antiretroviral therapy;
CD4 + /CD8 +;
Influencing factors
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(5):472-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the variation of CD4 + /CD8 + ratio and related influencing factors after receiving antiviral treatment for HIV/AIDS in Shandong province. Methods:HIV/AIDS patients in Shandong province initially received HAART from 2010 to 2015, at least 15 years old with the CD4 + T and CD8 + T cell count tested at baseline, 6 months, 1 year, 2 years, 3 years, 4 years and 5 years after treatment initiation were selected. According to their retrospectively collected baseline and follow-up data, the variation of CD4 + /CD8 + and the related influencing factors were described and analyzed by using rank sum test and generalized estimating equation(GEE). Results:A total of 557 subjects were included in the study. The median baseline CD4 + /CD8 + ratio was 0.20, and the CD4 + /CD8 + ratio was inverted in 99.82% of the patients. The proportion of patients with CD4 + /CD8 + ratio > 1 was 0.18% at baseline, and increased to 13.11% after 5 years of treatment. The trend of time change was statistically significant ( χ2 =95.01, P< 0.05). The result of GEE analysis showed that baseline CD4 + T lymphocytes count level and baseline symptoms/signs were the main factors influencing the variation trend of CD4 + /CD8 + ratio. Conclusions:After 5 years of antiviral treatment with HIV/AIDS in Shandong province, the CD4 + /CD8 + ratio increased significantly. Baseline CD4 + T cell count level and baseline symptoms/signs of patients are the main factors affecting the rate of improvement of CD4 + /CD8 + ratio.
