Progress toward gene therapy for the treatment of AIDS

VernacularTitle:艾滋病基因治疗的研究进展
Author: Jiaqi WEI ¹ ; Lei XU ; Haoquan WU ; Danlei MOU ; Hao WU ; Tong ZHANG ; Bin SU
Author Information

1. 首都医科大学附属北京佑安医院感染中心艾滋病研究北京市重点实验室，北京　100069
Keywords: Human immunodeficiency virus (HIV); Acquired immunodeficiency syndrome (AIDS); Gene therapy
From: Chinese Journal of Experimental and Clinical Virology 2020;34(4):453-458
CountryChina
Language:Chinese
Abstract: With the continuous development of gene therapy, more new technologies have been found and gradually applied in the basic research and clinical treatment of various diseases. In the field of AIDS treatment, gene therapy shows obvious advantages over traditional antiretroviral therapy. In recent years, short hairpin RNA (shRNA), clustered regulatory interspaced short palindrome repeat (CRISPR), transcription activator-like effector nucleases (TALEN), and zinc finger nucleases (ZFN) have been applied in AIDS treatment and have fruitful results. This paper reviews the major breakthroughs in this field since the emergence of gene therapy and the latest research achievements and their progress, with a view to providing a useful reference on a wider range of gene therapy application.