STUDY OF LOSS OF HETEROZYGOSITY AT DCC AND APC/MCC GENETIC LOCI OF GASTRIC CANCER
- Author:
Dongxu WANG
1
;
Dianchun FANG
;
Yuanhui LUO
;
Rong LU
;
Weiwen LIU
Author Information
1. Southwest Hospital,Third Military Medical University
- Keywords:
loss of heterozygosity;
DCC gene;
APC/MCC gene;
gastric cancer
- From:
Chinese Medical Sciences Journal
1999;14(2):107-111
- CountryChina
- Language:Chinese
-
Abstract:
In order to assess the role of the changes of DCC and APC/MCC genes in the development and progression of gastric cancer, the loss of heterozygosity (LOH) of these genetic loci was investigated in 45 surgical specimens of gastric cancer with PCR-RFLP. The rate of LOH was 30.0% (9/30)at APC/MCC gene and 33.3% (15/45) at DCC gene. LOH was found in both intestinal and gastric types of gastric cancer and the rate of LOH of DCC gene was significantly higher in stages Ⅲ～Ⅳ gastric cancer (48.0%) than in stages Ⅰ～Ⅱ (15.0%) (P＜0.05). LOH of APC/MCC gene could be found in both early and advanced stages of gastric cancer. These findings suggest that changes of DCC and APC/MCC genes are involved in the development and progression of the intestinal and gastric types of gastric cancer.
