Analysis of epidemiological and pathogenic characteristics of a mumps outbreak in a school in Xining, Qinghai province
10.3760/cma.j.cn112866-20200327-00094
- VernacularTitle:西宁市一起学校流行性腮腺炎暴发疫情流行病学和病原学特征分析
- Author:
Zhifang ZHANG
1
;
Ning XU
;
Jing WU
;
Chonghai LI
;
Xiaotong WANG
;
Aili CUI
;
Lixia FAN
Author Information
1. 西宁市疾病预防控制中心 810000
- Keywords:
Mumps;
Outbreak;
Epidemiological characteristics;
Pathogenic characteristics
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(4):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the epidemiological and pathogenic characteristics of a mumps outbreak in a primary school in Xining, Qinghai province.Methods:The epidemiological investigation was carried out to analyze the epidemiological distribution of mumps cases in the outbreak. Serum and throat swab samples were collected from 9 suspected mumps cases for laboratory testing. The throat swab samples detected positive for nucleic acid of mumps virus were subjected to virus isolation. Then the SH gene was amplified by RT-PCR for positive virus isolates, and the genotypes of mumps virus were identified and gene characteristics were analyzed.Results:A total of 13 cases were reported in this outbreak. The age of cases was mainly 7-11 years old, and the cases were mainly concentrated at 8 years old (69.23%. 9/13). The male to female ratio is 1.6: 1. None of the 13 cases had a history of mumps vaccination. And there was an obvious in-class clustering in this mumps outbreak. Of the 9 suspected mumps cases, 8 were double positive for mumps specific IgM antibody and viral nucleic acid. Two positive mumps virus isolates were obtained and identified by genotyping as F genotype, and the SH gene sequence of the two mumps virus isolates had 100% homology.Conclusions:This outbreak is caused by genotype F mumps virus. MuV immunization activities were recommended to conduct among unvaccinated students in primary and secondary schools.
