CIRCULATING INTERCELLULAR ADHESION MOLECULE 1 LEVELS IN SERA OF BRONCHIAL ASTHMA
- Author:
Guoqiang CAO
1
;
Zhaoheng YANG
;
Jigao SHEN
;
Tianxing LI
Author Information
1. 第三军医大学附属大坪医院(野战外科研究所)
- Keywords:
adhesion molecule;
intercellular adhesion molecule 1;
bronchial asthma
- From:
Chinese Medical Sciences Journal
1998;13(4):0-0
- CountryChina
- Language:Chinese
-
Abstract:
Objective.The aim of the study was to determine whether bronchial asthma was associated with increased levels of soluble intercellular adhesion molecule-1(Sicam-1) in serum, which might be valuble data for the effective therapy of these patients.Patients and methods.The concentrations of Sicam-1 were determined in sera of healthy donors and asthmatic patients using a sensitive enzyme immunoassay.Results.The mean(±SD) levels of serum Sicam-1 of 26 asthmatic patients (205±72.0 μg/L)was significantly higher than that of the 30 healthy volunteers (154±63.9 μg/L,P＜0.01). There was no much difference between the serum levels in 12 patients suffering from atopic asthma and the levels in 14 patients with nonatopic asthma. The serum concentrations of Sicam-1 were higher during asthma attacks than that during remissions in the same patients (P＜0.05).Conclusion.These results suggest that Sicam-1 may play a certain role in the pathophysiology of bronchial asthma,and might be signals for successful treatment.
