Analysis of the serum antibody test results and clinical diagnostic value in patients with novel coronavirus pneumonia
10.3760/cma.j.cn112866-20200313-00064
- VernacularTitle:423例新型冠状病毒肺炎患者血清抗体检测结果与临床诊断应用价值研究
- Author:
Xiong LIU
1
;
Yuehua KE
;
Wei LIU
;
Chaojie YANG
;
Zhihua WANG
;
Yi TENG
;
Qinghua QIAO
;
Hao LIU
;
Rong ZHANG
;
Ruizhong JIA
;
Leili JIA
;
Yong CHEN
;
Changjun WANG
;
Xiaoli XU
;
Xinyi XIA
Author Information
1. 武汉火神山医院 430100；解放军疾病预防控制中心，北京 100071
- Keywords:
COVID-19;
Antibodies;
Clinical diagnosis
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(3):231-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To provide reference for clinical case diagnosis and treatment applications using descriptive analysis of patient-specific IgM and IgG test result of novel coronavirus pneumonia (COVID-19).Methods:Chemical luminescence was used to detect the levels of 423 confirmed or suspected cases IgM and IgG antibody, and the test result of patients with different clinical characteristics were compared and analyzed.Results:The positive rates of confirmed cases of COVID-19 were 80.4% (314/388) and 98.2% (381/388), for IgM and IgG respectively, and the positive rates of COVID-19 suspected cases specific IgM and IgG were 0.0% (0/24) and 45.8% (11/24), respectively. In patients at 6 weeks or more after the onset of the disease, the positive rate of IgG antibody was 100%. The level of IgG titer was generally higher in cases of 5~8 weeks after onset (mean: 112.70 AU/ml) than in cases of 1-4 weeks after onset (mean: 85.01 AU/ml) (U=8 531, P<0.0001). The level of IgG titer was higher in severe type cases than that of patients with ordinary type illness, with an average of 137.61 AU/ml. Conclusions:Specific IgM and IgG antibodies have strong application value in COVID-19 case diagnosis, and it is recommended to strengthen the tracking and monitoring of IgM and IgG titer levels in patients.
