Dyslipidemia and relevant factors analysis of HIV/AIDS patients in general hospital
10.3760/cma.j.cn112866-20191030-00168
- VernacularTitle:306例艾滋病患者的血脂异常情况及相关因素分析
- Author:
Minhong YU
1
;
Yanwei ZHAO
;
Hui YANG
;
Xiaojing SONG
;
Ye HE
;
Jiaqian LI
;
Xiaojuan ZHANG
Author Information
1. 中国医学科学院北京协和医院，北京 100730
- Keywords:
AIDS;
Dyslipidemia;
Antiretroviral therapy;
Life style
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(2):122-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate dyslipidemia and relevant factors of AIDS patients in general hospital.Methods:From April 2017 to January 2018, 306 AIDS patients seen in Peking Union Medical College Hospital (PUMCH) were included, their general information such as demographic characteristics, underlying diseases, regimens for treatment and duration of antiretroviral therapy were recorded and dietary conditions were evaluated. General Self-Efficacy Scale (GSES), Social Support Rating Scale (SSRS), Internal Physical Activity Questionnaire (IPAQ) were adopted for the investigation.Results:Of the 306 patients, 179 had dyslipidemia. Univariate analysis suggested that singlehood, higher age and body mass index (BMI), proteinase inhibitor (PI) and non-nucleotide reverse transcriptase inhibitor (NNRTI) contained antiretroviral therapy (ART) (especially the former) were relevant risk factors. After multivariable analysis, higher age and BMI, high fat diet, high baseline CD4 counting and longer course of disease were related with dyslipidemia, whereas female and higher activity level may be associated with little benefit.Conclusions:Dyslipidemia was more common in AIDS patients than in general population, which were mainly due to the disease itself and ART regimens. Those patients were middle-aged or older, with high baseline CD4 counting, treated with PI and whose course of disease was more than two years should reserve more attention.
