Loss of long-lived memory CD8 + T cells and its clinical implication in chronic HIV-1 infected individuals
10.3760/cma.j.cn112866-20191015-00158
- VernacularTitle:长期记忆CD8 ＋T细胞的减少与HIV-1慢性感染进程相关性分析
- Author:
Mingju ZHOU
1
;
Jiehua JIN
;
Jing LI
;
Wenjing CAO
;
Chunbao ZHOU
;
Jinwen SONG
;
Chao ZHANG
;
Fusheng WANG
Author Information
1. 蚌埠医学院 233000
- Keywords:
Human immunodeficiency virus;
Long-lived memory CD8 + T;
Disease progression
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(2):128-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of long-lived memory CD8 + T cells and its relationship with disease progression in HIV-1 infected patients. Methods:Twenty-six treatment-na?ve and 26 antiretroviral therapy (ART)-treated HIV-1 infected patients, as well as 11 healthy controls were recruited in this study. Peripheral blood mononuclear cells were isolated and analyzed by flow cytometry to detect the frequency and function of long-lived memory CD8 + T cells. Results:The frequency of long-lived memory CD8 + T cells decreased significantly in treatment-na?ve patients compared with that in healthy controls, and was not fully restored in ART-treated group. In addition, the frequency of long-lived memory CD8 + T cells is positively correlated with CD4 + T cell count and CD4/CD8 ratio, while negatively correlated with HIV-1 viral load. Conclusions:The disease progression in chronic HIV-1 infected individuals is accompanied by continuous damage to long-lived memory CD8 + T cell.
