Pathogen spectrum of febrile respiratory syndrome in Guangdong province from 2011 to 2018
10.3760/cma.j.cn112866-20191029-00165
- VernacularTitle:2011—2018年广东省发热呼吸道症候群病原谱研究
- Author:
Rongfei CHE
1
;
Congrong LI
;
Dan LIANG
;
Hong XIAO
;
Lina YI
;
Changwen KE
Author Information
1. 汕头大学医学院 515041
- Keywords:
Febrile;
Respiratory infection;
Pathogen;
Surveillance;
Polymerase chain reaction
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(2):133-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the pathogenic spectrum and epidemiological characteristics of febrile respiratory syndrome in Guangdong province, and to provide reference for disease prevention, clinical diagnosis and treatment.Methods:The pathogens of 1 891 nasopharyngeal swabs collected from 2011 to 2018 were detected by real-time fluorescent polymerase chain reaction. The different rates were compared by chi-square test or Bonferronni method of comparison.Results:Among 1 891 samples, 810 samples were positive for viral nucleic acid, with a total detection rate of 42.78%. The main infectious agents were Parainfluenza virus (PIV), Rhinovirus (RhV) and Coronavirus(CoV). The pathogen detection rate was higher in <5 years group and 5~ years group. Pathogen detection in patients with different symptoms showed that the detection rate of Metapneumovirus (MPV) in pneumonia patients was relatively high. Influenza virus A (FluA), PIV, CoV and RhV had higher detection rate in patients without pneumonia. FLuA and Adenovirus (ADV)had a relatively high detection rate in the high and ultra-high fever groups. The detection rate of CoV and Mycoplasma pneumonia(MP) in moderate fever group was relatively high. The detection rate of PIV in cough patients was relatively high. The prevalence of several viruses has strong seasonality, and the detection rate was generally higher in winter and spring. Different virus detection rates also have strong regularity in years.Conclusions:PIV, RhV and CoV are the main pathogens of febrile respiratory syndrome in Guangdong in recent years.
