Research progress in the effect of HIV-1 Tat protein on oxidative stress of vascular endothelial cells and nerve cells in brain tissue
10.3760/cma.j.cn112866-20200224-00029
- VernacularTitle:HIV-1 Tat蛋白对脑组织中血管内皮细胞和神经细胞氧化应激影响的研究进展
- Author:
Shuaizhi GUO
1
;
Tao HUANG
;
Li ZHAO
Author Information
1. 山东大学公共卫生学院卫生微生物检验学系 山东省"十三五"高校重点实验室，济南 250012
- Keywords:
Human immunodeficiency virus-1;
Tat protein;
Oxidative stress;
Vascular endothelial cells;
Nerve cells
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(2):217-220
- CountryChina
- Language:Chinese
-
Abstract:
HIV-1 can cross the blood-brain barrier, infect the central nervous system, and cause a series of nervous system diseases. Oxidative stress (OS) plays an important role in the pathogenesis of different neurodegenerative diseases. When the body is subjected to various harmful stimulation, the regulation level of oxidation system and antioxidant system is out of balance, producing a large number of reactive oxygen species, which directly or indirectly leads to tissue damage. Tat protein, a trans-activator of transcription released after HIV-1 infection, plays an important role in brain injury. It can induce endothelial cells and nerve cells to produce living oxygen, make the body in a state of chronic oxidative stress, and aggravate the development of the disease. In this paper, the research progress in studies on the effect of HIV-1 Tat protein on oxidative stress of vascular endothelial cells and nerve cells was reviewed.
