Dengue virus and cell autophagy
10.3760/cma.j.issn.1003-9279.2020.01.022
- VernacularTitle:登革病毒与细胞自噬
- Author:
Sen YANG
1
;
Shiyou LIU
;
Yamei WEI
;
Xu HAN
;
Yanan CAI
;
Zhanying HAN
;
Shunxiang QI
;
Qi LI
Author Information
1. 河北医科大学
- Keywords:
Autophagy;
Dengue virus;
Lipid droplets;
Virus replication
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(1):107-111
- CountryChina
- Language:Chinese
-
Abstract:
Dengue viruses(DENV) are seriously affected by cell autophagy in intracellular replication,transmission between host,and the pathogenic mechanism.Here,the latest research progress of complex interplay between DENV and cell autophagy were reviewed in this paper.Autophagy,a cellular procedural protein degradation pathway generally possessed by all eukaryotes plays a key role in response to outside pressure and maintaining cellular homeostasis.This catabolic pathway also promotes cell survival against the invasion of pathogens such as various viruses.However,autophagy plays an opposite role in the replication of DENV.Autophagy not only provides a replication site for viruses to replicate,but also provides a source of energy for this process.Cell autophagy also participates in the pathogenesis of some DENV infection.In short,autophagy contributes to the replication of DENV.
