A new connotation of neutrophil extracellular traps and bronchial asthma pathogenesis based on the basic principles of traditional Chinese medicine constitution
10.3969/j.issn.1006-2157.2024.05.014
- VernacularTitle:基于中医体质学基本原理探讨中性粒细胞胞外诱捕网与支气管哮喘发病的内涵
- Author:
Yuhan ZONG
1
;
Manting WANG
;
Fan YANG
;
Jingwei KONG
;
Ji WANG
Author Information
1. 广州中医药大学第二临床医学院 广州 510006
- Keywords:
traditional Chinese medicine constitution;
bronchial asthma;
neutrophils;
neutrophil extracellular traps
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(5):699-703
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma(asthma)is a common clinical respiratory disease mediated by multiple cells and components,and neutrophils,as one of the classic innate immune cells,play an important role in the pathogenesis of asthma.In the inflammatory state,neutrophils release neutrophils extracellular trap(NET)into the periphery through the NETosis procedure.Although NET is a beneficial antibacterial defense structure,its excessive accumulation can trigger different response mechanisms that can also adversely affect the lungs and exacerbate asthma.Based on the basic principles of traditional Chinese medicine constitution,exploring the important role of NET in the pathogenesis of asthma,it holds that the life process theory body-spirit composition theory,endowment inheritance theory,and environmental constraint theory are related to the gradual formation of NET and different stimuli affect the heterogeneity of NET,thereby mediating different biological effects during the onset of asthma.Targeting NET and/or its components may become a new treatment strategy on asthma.
