Mechanism of aggravated severity in hypertriglyceridemia-associated acute pancreatitis:insights from the pathogenesis of"fat-turbidity-toxic heat"
10.3969/j.issn.1006-2157.2024.05.011
- VernacularTitle:从"膏-浊-热毒"病机演变浅析高甘油三酯血症相关性急性胰腺炎重症化的机制
- Author:
Yuying LI
1
;
Xinmin YANG
;
Shaoqi ZHONG
;
Yulin LENG
;
Linbo YAO
;
Tingting LIU
;
Tao JIN
;
Qing XIA
;
Wei HUANG
Author Information
1. 四川大学华西医院中西医结合中心,华西胰腺炎卓越中心 成都 610041
- Keywords:
hypertriglyceridemia-associated acute pancreatitis;
fat-turbidity-toxic heat;
free fatty acids;
multiple organ dysfunction syndrome
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(5):672-678
- CountryChina
- Language:Chinese
-
Abstract:
Hypertriglyceridemia-associated acute pancreatitis is an inflammatory disorder of exocrine pancreas caused by metabolism disturbances of triglyceride-rich lipoproteins.Currently,hypertriglyceridemia-associated acute pancreatitis is characterized by an escalating incidence rate,a tendency for more severe cases,and a lack of therapeutic drugs.Traditional Chinese medicine has distinct advantages in treating this disease,but its theoretical framework has not yet been established.Hypertriglyceridemia-associated acute pancreatitis manifests itself as a febrile disease,aberrant accumulation of fat and turbidity may stem from dietary imbalances and visceral dysfunction in ordinary individuals.The prolonged accumulation of fat and turbidity can transform into turbid pathogen,subsequently engendering heat,constituting a pivotal pathogenic factor.Throughout the progression of the disease,the fiery pathogen consumes the fat and turbidity,resulting in the generation of toxic heat,which is a crucial mechanism in the exacerbation of the disease severity.Thus,this article posits therapeutic principles aimed at averting the transformation of fat and turbidity into turbid pathogen and counteracting toxic heat in this disease.This article reviews two key theories from traditional Chinese medicine classics relevant to hypertriglyceridemia-associated acute pancreatitis:the theory of fat-turbidity associated with hypertriglyceridemia and the febrile disease related to acute pancreatitis.Combining these traditional theories with modern research on the mechanisms that intensify hypertriglyceridemia-associated acute pancreatitis and the corresponding targets of traditional Chinese medicine,it suggests that the pathogenesis of"fat-turbidity-toxic heat"serves as the theoretical basis of traditional Chinese medicine for the aggravated severity of hypertriglyceridemia-associated acute pancreatitis.The article aims to offer new insights for the treatment of hypertriglyceridemia-associated acute pancreatitis.
