Analysis on respiratory syncytial virus infection in infants and young children and the relationship with interleukin-4
10.3760/cma.j.issn.1003-9279.2016.06.017
- VernacularTitle:探讨婴幼儿呼吸道合胞病毒感染及与白介素4的相关性
- Author:
Qing'e JIN
1
;
Shanna WU
;
Yuhua LIU
;
Junchao GU
;
Jianrong SU
Author Information
1. 100050,北京首都医科大学附属北京友谊医院检验科
- Keywords:
Respiratory syncytial virus;
Acute respiratory infection;
Interleukin-4
- From:
Chinese Journal of Experimental and Clinical Virology
2016;30(6):570-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze respiratory syncytial virus infection in infants and young children during 2014 and explore the relationship of infection status with the level of interleukin-4 in serum samples.Methods Totally 150 children with ARI were recruited in this study,and collected throat swabs from them.RSV was identified and differentiated into subgroups A and B by real-time RT-PCR.The total of IL-4 concentration in serum samples was measured by ELISA.Results Out of the 150 samples,32 (21.33％) were positive for RSV.Subtyping for A and B showed that 25 cases were subgroup A and 7 cases were subgroup B.Comparing between RSV infection group and normal control group,the former had higher serum IL-4 level [(328.67 ± 52.96) ng/L vs.(217.34 ± 51.21) ng/L,P ＜ 0.01],additionally B subgroup presented higher concentration than A subgroup [(371.09 ± 61.96)ng/L vs.(316.80 ± 44.63) ng/L,P ＜ 0.05].Analysis of clinical data indicated that infection of B subgroup probable caused more serious wheeze symptoms than that by subgroup A.Conclusions Infection of RSV subtype A was predominant in Oct.2014 to Mar.2015.Level of serum IL-4 was increased statistical significantly after RSV infection.Furthermore,infection of subtype B might cause more severe illness.
