Pathogen spectrum analysis of hand, foot and mouth disease in 2014 in Beijing Youan hospital
10.3760/cma.j.issn.1003-9279.2016.06.012
- VernacularTitle:2014年北京佑安医院手足口病病原谱分析
- Author:
Haiqing SUN
1
;
Junhong LI
;
Jian ZHANG
;
Hongxin WANG
;
Sheng ZHANG
;
Junping ZHU
;
Jinli LOU
Author Information
1. 首都医科大学附属北京佑安医院
- Keywords:
Hand,foot and mouth disease;
Epidemiology;
Pathogen spectrum
- From:
Chinese Journal of Experimental and Clinical Virology
2016;30(6):549-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the pathogen spectrum of hand,foot and mouth disease (HMFD)in 2014 in Beijing Youan Hospital for providing scientific basis for the prevention of HFMD.Methods The related data of HFMD in 2014 was analyzed by LIS system,including the characteristics of pathogen spectrum.The other enterovirus(EV) was partially identified by DNA sequencing analysis.Results The number of confirmed HMFD cases in 2014 was 2 031,and the proportion of male and female patients was about 1.5:1.The pathogen spectrum of HMFD was EV-A71 (34.6％),CVA16 (34.6％) and other EV (30.8％).The HMFD peak of incidence was from April to August in 2014.During the period,the composition ratios of EV-A71,CVA16 and other enterovirus were respectively 46.5％/30.8％/22.7％、41.3％/29.6％/29.1％ 、31.8％/38.4％/29.8％ 、32.6％/36.1％/31.3％ 和 30.9％/37.4％/31.7％ in each month.The difference among them was statistically significant (chi-square =x2 =24.866,P =0.002 ＜ 0.05).During the period of high incidence of HFMD,the predominant patients were the children under five years old,the younger the age,the higher the incidence rate.Conclusions The major causative agents of HFMD in 2014 are still EV-a71 and CVA16.The other EV encounters a considerable proportion and the incidence of CVA10 and CVA6 is relatively higher,which could cause severe cases of HFMD.
