Analysis of TCM syndrome characteristics and factors associated with early death in higher-risk patients with myelodysplastic syndromes with excess blasts
10.3969/j.issn.1006-2157.2024.03.018
- VernacularTitle:较高危骨髓增生异常综合征伴原始细胞增多患者的中医证候特征及早期死亡危险因素研究
- Author:
Shengqi ZHANG
1
;
Peizhen JIANG
;
Yan GAO
;
Qingguo LIU
;
Chaochang ZHANG
;
Xudong TANG
Author Information
1. 北京中医药大学研究生院 北京 100029
- Keywords:
myelodysplastic syndromes;
risk factors for death;
blasts;
Charlson comorbidity index score;
TCM syndrome characteristics;
retrospective analysis
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(3):429-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective We aimed to investigate the TCM syndrome characteristics and risk factors of early death in higher-risk patients with myelodysplastic syndromes with excess blasts (HR-MDS-EB). Methods The data of 57 HR-MDS-EB patients in the hematology ward of Xiyuan Hospital, China Academy of Chinese Medical Sciences admitted between January 2013 and August 2020 were analyzed. Patients were divided into an early death group and a non-early death group according to the survival time. The basic information, clinical characteristics, specialized examination, complete blood cell counts and laboratory examination result for first diagnosis, TCM syndrome characteristics, and other data of patients were collected and analyzed to screen the risk factors of death.Results There were statistically significant differences in Charlson comorbidity index (CCI) score, Barthel index score, platelet count at first diagnosis, blast ratio in peripheral blood, lactate dehydrogenase levels, blazing pathogenic heat pattern, and constipation between the early death group and the non-early death group (P<0.05). According to the result of the above univariate analysis, logistic multivariate regression analysis was performed for significant factors P<0.05. CCI score had statistically significant effects on the risk of death (P<0.05).Conclusion Higher CCI score is an independent risk factor for early death in HR-MDS-EB patients.
