Exploration of the pathogenesis and treatment of Cronkhite-Canada syndrome from the perspective of " endogenous toxins cause the disease"
10.3969/j.issn.1006-2157.2024.03.015
- VernacularTitle:从"内毒致病"探讨克朗凯特-卡纳达综合征的病机及治疗
- Author:
Kunhan SU
1
;
Yuzhen HUANG
;
Wanli LIU
Author Information
1. 南京中医药大学附属南京市中西医结合医院 南京 210014
- Keywords:
Cronkhite-Canada syndrome;
endogenous toxins cause the disease;
polyp;
pathogenesis;
treatment
- From:
Journal of Beijing University of Traditional Chinese Medicine
2024;47(3):407-411
- CountryChina
- Language:Chinese
-
Abstract:
Cronkhite-Canada syndrome is a disease characterized by multiple polyps and changes in the ectoderm of the digestive tract, but its etiology and pathogenesis have not been completely elucidated. Endogenous toxins are a special class of intrinsic pathogenic factors, which are released upon visceral dysfunction and abnormal movement of qi and blood. Endogenous toxins can hide deeply in the body, they can enter the meridians and collaterals, and they can be mixed with phlegm and blood stasis. Endogenous toxins can damage the skin externally, corrode the internal organs, attack hands and feet, and damage the vital qi. The pathogenesis of Cronkhite-Canada syndrome can be understood from the perspective of " endogenous toxins cause the disease". Dampness-heat due to spleen deficiency and dampness toxin accumulation are the fundamental causes of Cronkhite-Canada syndrome. The mutual fusion of phlegm toxin and blood stasis toxin is the pathological essence of the diffuse growth of gastrointestinal polyps in Cronkhite-Canada syndrome. The internal toxin transformation process of "dampness toxin-phlegm stasis toxin-cancer toxin" may be a potential mechanism for the occurrence of cancer. The treatment of Cronkhite-Canada syndrome should be based on the principle of strengthening the spleen, removing dampness, and detoxification. Among them, strengthening the spleen is the foundation, removing dampness is the key, and detoxification is the core. The treatment of Cronkhite-Canada syndrome can be achieved through methods such as strengthening the spleen and infiltrating dampness, promoting diuresis and detoxification, resolving phlegm, and removing blood stasis. At the same time, correcting the patient's biased constitution should be used as an auxiliary treatment method, and treatment based on a combination of traditional Chinese and western medicine should be emphasized.
