P14 Rotavirus VP8* protein specifically binds to a type histo-blood group antigen
10.3760/cma.j.issn.1003-9279.2016.03.015
- VernacularTitle:P[14]型轮状病毒VP8*蛋白特异结合A型组织血型抗原
- Author:
Xiaoman SUN
1
;
Nijun GUO
;
Ziqian XU
;
Dandi LI
;
Zhaojun DUAN
Author Information
1. 中国疾病预防控制中心病毒病预防控制所
- Keywords:
P[14] rotavirus;
VP8 * protein;
Histo-blood group antigens
- From:
Chinese Journal of Experimental and Clinical Virology
2016;30(3):315-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the binding specificity of the P[14] RV detected directly from the stool samples.Methods The P[14] VP8* protein was expressed and purified and then the binding pattern to synthetic oligosaccharides and saliva samples was carried out.Results The P[14] VP8 * protein showed significant binding to A type HBGA while almost no binding was detected to other HBGAs.Conclusions A-HBGA may be the attachment factor for the P[14] rotavirus.Therefore,the research of the interaction between P [14] RV and HBGAs provides the basis for further characterization of binding patterns of other RV genotypes and the RV surveillance.
