Administrative features of Chinese medicinals in treatment of diabetic macular edema
10.3969/j.issn.1006-2157.2018.05.014
- VernacularTitle:中药治疗糖尿病黄斑水肿临床用药特征探讨
- Author:
Yuanchun HU
1
;
Chuanhong JIE
;
Zhengzheng WU
;
Wenjing CAI
;
Jianwei WANG
Author Information
1. 中国中医科学院眼科医院 北京100040
- Keywords:
Chinese medicine and pharmacy;
data mining;
diabetic macular edema;
administrative char-acteristics of medicinal
- From:
Journal of Beijing University of Traditional Chinese Medicine
2018;41(5):434-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the law of medicinals and discuss rules of clinical administration of Chinese medicinals and features of pattern differentiation and treatment in treatment of diabetic macular e -dema(DME).Methods The literature using TCM decoctions for treating DEM published at home and abroad were collected, analyzed and studied by applying modern computer data mining technology The core medicinals,core couplet medicinals and core medicinal combinations were analyzed,and the presic-riptvons law was explored.Results A total of 54 articles were included in this study involving 99 kinds of medicinals with a total frequency of 540 counts.The top ten frequent single medicinals were Fuling (Indian Bread, Poria), Zexie(Oriental Waterplantain Rhizome, Rhizoma Alismatis), Huangqi (Milkvetch Root,Radix Astragali seu Hedysari), Danggui(Chinese Angelica, Radix Angelicae Sinen-sis),Chuanxiong(Sichuan Lovage Rhizome,Rhizoma Ligustici Chuanxiong), Zhuling(Chuling,Pol-yporus),Shengdihuang(Unprocessed Rehmannia Root,Radix Rehmanniae Recens),Baizhu(White At-ractylodes Rhizome,Rhizoma Atractylodis Macrocephalae),Danshen(Salvia Root,Radix Salviae Miltior-rhizae), and Cheqianzi(Plantain Seed, Semen Plantaginis).There were 19 types of TCM patterns, which were divided into 3 categories: phlegm-stasis obstruction, spleen deficiency and water retention, and qi-blood and yin-yang deficiency.The top four couplet medicinals according to association rules were Fuling-Huangqi,Fuling-Zexie,Chuanxiong-Danggui,Fuling-Danggui.The top three-medicinal combi-nations according to association rules were Fuling-Chuanxiong-Danggui, Zexie-Danggui-Fuling, and Fuling-Zexie-Huangqi.The top three four-medicinal combinations according to association rules were Zexie-Chuanxiong-Danggui-Fuling, Chuanxiong-Danggui+Huangqi+Fuling, and Zexie-Danggui-Huan-gqi-Fuling.Conclusion DME was treated mainly with medicinals with effects of tonifying qi and indu-cing dieresis,and with medicinals with effects of activating blood and enriching blood to supplement.The TCM pathogenesis of DME is qi-blood and yin-yang deficiency leading to internal water retention,binding of phlegm-stasis and obstruction of ocular collaterals over the time.
