Influence of Peiyuan Tongluo Fang on clinical efficacy and micro-inflam-mation state in patients with diabetic kidney disease
10.3969/j.issn.1006-2157.2018.05.013
- VernacularTitle:培元通络方对糖尿病肾脏病临床疗效及微炎症状态的影响
- Author:
Hong LIU
1
;
Weijian XIONG
;
Ying LI
;
Lingyun ZHONG
;
Xiaoli ZHOU
;
Xin ZHENG
Author Information
1. 重庆市中医院肾病科 重庆400021
- Keywords:
Peiyuan Tongluo Fang(Qi-tonifying Collateral-dredging Decoction);
diabetic kidney dis-ease;
micro-inflammation state
- From:
Journal of Beijing University of Traditional Chinese Medicine
2018;41(5):428-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of Peiyuan Tongluo Fang(Qi-tonifying Collateral-dred-ging Decoction,PTF)on clinical efficacy and micro-inflammation state in patients with phase IV diabetic kidney disease(DKD),and investigate the mechanism of PTF in treatment of DKD.Methods Phase IV DKD patients(n=106)were randomly divided into treatment group and control group(each n=53).There were actually 98 patients had complete treatment in 2 groups(each n=49).Besides of basic therapy,the treatment group was treated with PTF,and control group was treated with Niaoduqing Gran-ule for 8 weeks.The changes of TCM patterns and levels of serum creatinine(SCr),estimated glomeru-lar filtration rate(eGFR),24 h urinary protein excretion(24 h U-pro), urinary microalbumin protein (U-Alb),high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleu-kin-6(IL-6)were observed and analyzed statistically in two groups.Results After treatment,all TCM patterns were significantly relieved(P<0.05 or P<0.01)in treatment group compared with before, which were superior to those in control group(P<0.05 or P<0.01).After treatment,levels of SCr,24 h U-pro and U-Alb decreased significantly(P<0.01)and eGFR level increased(P<0.05)in treat-ment group compared with before treatment,which were superior to those in control group(P<0.05 or P<0.01).After treatment, levels of hs-CRP, TNF-αand IL-6 decreased significantly(P <0.01)in treatment group compared with before treatment, which were superior to those in control group(P <0.05).The total effective rate was 73.47%(36/49)in treatment group,and 44.90%(22/49)in con-trol group(P<0.05).No adverse reactions were observed in 2 groups.Conclusion PTF combined with basic therapy of Western medicine can effectively reduce urine protein,protect kidney and alleviate micro-inflammation state in patients with phase IV DKD.
