The expression of TLR7/9 and associated signaling pathway proteins in condyloma accuminatum lesions
10.3760/cma.j.issn.1003-9279.2016.01.007
- VernacularTitle:尖锐湿疣患者皮损中 TLR7／9相关信号通路蛋白的表达
- Author:
Xiaoxia ZHU
1
;
Qiang ZHOU
;
Hao CHENG
;
Rui HAN
;
Hongming ZHU
Author Information
1. 宁波市第一医院
- Keywords:
Condyloma accuminatum;
TLR7;
TLR9;
IRF7;
IRAK1;
Papillomavirus,human
- From:
Chinese Journal of Experimental and Clinical Virology
2016;(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of TLR7/9, IRF7 and IRAK1 in condyloma accuminatum (CA) lesions and to investigate their possible roles in pathogenesis of CA.Methods The expressions of TLR7/9, IRF7 and IRAK1 in 23 cases of CA lesions were tested by immunohistochemistry. Results TLR9-positive cells were observed both in the epidermis and in the papillary layer of dermis.The density and positive rate of TLR9-positive cells in the papillary layer of CA lesions were significantly higher than those in their normal borderline tissues ( P <0.05 ) .TLR7-positive cells, IRF7-positive cells and IRAK1-positive cells were observed mostly in the papillary layer of dermis.There were no obvious difference of their density and positive rate between the CA lesions and their normal borderline tissues ( P>0.05 ) . Conclusions The TLR9 expression was up-regulated,while the TLR7, IRF7 and IRAK1 expression were un-changed in CA lesions.Our results suggested that the downstream of TLR7/9 signaling pathways in CA could not be provoked despite the up-regulation of TLR9 expression, which lead to the difficulty to HPV removal and the recurrence of CA.
