Prevalence of multiple types of human adenovirus infection among children with severe acute respiratory infection in Shanghai
10.3760/cma.j.issn.1003-9279.2016.01.003
- VernacularTitle:上海市重症急性呼吸道感染儿童中可检出多种型别的人腺病毒
- Author:
Yamin LI
1
;
Gaoshan LIU
;
Weimin ZHOU
;
Yanjie ZHAO
;
Yuchuan LI
;
Jun SHEN
;
Wenjie TAN
Author Information
1. 中国疾病预防控制中心 病毒病预防控制所应急技术中心
- Keywords:
Severe acute respiratory infection;
Children;
Human adenovirus;
Typing detection
- From:
Chinese Journal of Experimental and Clinical Virology
2016;(1):10-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the typing profiles of human adenovirus infection among children with severe acute respiratory infection ( SARI ) in Shanghai. Methods A total of 441 nasopharyngeal aspirates ( NPAs) were collected from hospitalized children with SARI in Shanghai Pediatrics Hospital Affiliated Fudan University from June 2013 to March 2014.Human adenovirus was detected by nested PCR followed molecular typing by sequencing.Then the phylogenetic and epidemiological analysis was conducted.Results From 441 hospitalized children with SARI, 51 of samples ( 11.6%, 95%CI:8.6%~14.6%) were detected as HAdV infection.Most of the SARI children with HAdV infection were distributed between 0.5 to 5 years old.Typing data shown that HAdV-B (17 of HAdV-3, 16 of HAdV-7) was most dominant as 64.7%(33/51),followed by HAdV-C as 27.5%(14/51);either HAdV-D (HAdV-8) or HAdV-E ( HAdV-4 ) contained only one case, and HAdV-F ( HAdV-41 ) found in two cases. Conclusion Multiple species( B-F) of HAdVs were circulated among children with SARI in Shanghai, and HAdV-B (HAdV-3, HAdV-7) was the most predominant species of circulation.
