Network pharmacological studies of Mongolian compound formula Xieri-ga-4
10.3969/j.issn.1006-2157.2018.02.008
- VernacularTitle:蒙药复方协日嘎-4的网络药理学研究
- Author:
Feng BAI
1
;
Binxin LI
;
Yu DONG
;
Tianming ZHANG
Author Information
1. 内蒙古医科大学药学院 内蒙古010110
- Keywords:
network pharmacology;
Xieriga-4;
multi-component and multi-target;
signaling pathway;
mechanism of action
- From:
Journal of Beijing University of Traditional Chinese Medicine
2018;41(2):140-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to explore the active ingredient and action target of Mongolian medicine compound formula Xieriga-4 in the treatment of benign prostatic hyperplasia, prostate cancer and other diseases.The mechanism of the chemical composition of Xieriga-4 was analyzed by using net-work pharmacology technology.Methods By searching China National Knowledge Infrastructure (CNKI),Wanfang database and other databases,Mongolian compound formula Xieriga-4's composition was identified.PubMed,Super Target,Drug Bank,TTD(Targets Database Therapeutic)and other da-tabase were used to search for action targets of the chemical composition of Xieriga-4;KEGG(Kyoto En-cyclopedia of Genes and Genomes),IPA(Ingenuity Pathway Analysis)and other database were searched to explore relevant signal pathway;Cytoscape software was applied to establish the chemical constituents-target and chemical composition-target-disease network model of the Mongolian compound formula Xieri-ga-4.Results The correlation between drug and target provided a new way to explore potential targets.The screening results showed that Mongolian drug compound formula Xieriga-4 has network interaction in 33 compounds and 12 kinds of biological targets,the correlation among which implied the"multi-compo-nent","multi-target"characteristic of online pharmacology.Meanwhile the compounds and target sites act together on disease-benign prostatic hyperplasia and prostate cancer, and the Mongolian compound Xieriga-4-chemical composition-target-disease network mode could thus be established.Through the data-base searching,two major signal pathways were identified, i.e.AR signal pathway and Wnt/-catenin signaling pathway,which provided a new idea for Mongolian medicine to explore the mechanism of dis-ease treatment.Conclusion This study has established a"disease-target-drug"model by using internet-based pharmacology,which could be a new approach to the research and development of Mongolian medi-cine.
