Expression of eIF-4A protein in cervical carcinoma and its clinical significance
10.3760/cma.j.issn.1003-9279.2015.06.012
- VernacularTitle:宫颈癌组织中eIF-4A蛋白的表达及其临床意义研究
- Author:
Tinghua ZHENG
1
;
Wangqian HUA
;
Xiaojie YANG
;
Wei HAN
;
Yukun ZHOU
;
Wei ZHENG
Author Information
1. 063000,唐山市妇幼保健院妇产科
- Keywords:
Cervix neoplasms;
Intraepithelial neoplasia;
Immuno ochemistry;
eIF-4A
- From:
Chinese Journal of Experimental and Clinical Virology
2015;29(6):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of eIF 4A in cervical cancer and different levels of cervical neoplasia tissues and its clinical significance.Methods 80 cases of cervical cancer were included in the diagnosis of cervical cancer,40 patients with high cervical intraepithelial neoplasia (CIN grade Ⅱ and grade Ⅲ) and 40 cases of low grade cervical intraepithelial neoplasia (CIN Ⅰ) were incorporated into the experimental group between February 2012 and March 2015 in hospital,and patients with total hysterectomy,pathological diagnosis of normal cervix were included in the control group.Expression level of eIF-4A protein in cervical cancer tissues,different levels of cervical neoplasia tissues and normal tissue was determined by immunohistochemical method,to investigate the relationship between the pathology and clinical grading and staging of cervical cancer.Results The expression of eIF-4A proteins in the different tissues were normal cervical tissue (0.0％),CIN Ⅰ (52.5％),CIN Ⅱ and Ⅲ (77.5％),cervical cancer(81.8％).The positive expression rate was gradually increasing trend,the difference was statistically significant (x2 =77.874,P ＜ 0.05),the linear trend test was statistically significant (x2 =65.810,P ＜ 0.05).The expression of eIF-4A proteins in CIN Ⅱ and Ⅲ have no significant difference (x2 =0.292,P ＞ 0.05).The expression of eIF-4A proteins in cervical cancer were independent of the type of organization (x2 =0.779,P =0.377);related to its histological grad(x2 =8.042,P =0.018);and related to its clinical staging(x2 =6.765,P =0.009).Conclusion The expression of eIF-4A proteins may be associated with the occurrence and development of cervical cancer,it may be plays a role in the cervical cancer initiation process.
