The epidemiologic and virological analysis of an outbreak of influenza A/H1N1

VernacularTitle:一起甲型H1N1流感暴发疫情的流行病学和病原学分析
Author: Haiyan HOU ¹ ; Pengfei YANG ; Minhui ZHANG ; Jing LIU ; Chuncheng LIU ; Yujun SHI
Author Information

1. 223001,淮安疾病预防控制中心
Keywords: Influenza A; H1N1 subtype; Outbreak; Sequence analysis
From: Chinese Journal of Experimental and Clinical Virology 2015;29(5):405-408
CountryChina
Language:Chinese
Abstract: Objective To study the epidemiological characters of an influenza A/H1N1 outbreak in a middle school in Huaian city,and to provide scientific measures for prevention and control of influenza A/ H1N1.Method The outbreak of influenza A/H1N1 was investigated through the field epidemiology.The samples were used for virus isolation.Nucleotide sequences of H1N1 HA1 region were determined by RT-nested-PCR and sequencing.H1N1 genotypes were analyzed using bioinformatic programs by MEGA 5.0 software,and phylogenetic tree was constructed.Result 51 cases were reported during 11 days,the attack rate was 2.49％ (51/2051).The sequence analysis showed that the sequence homologous rates of H1N1 virus HA gene nucleotide were 99.6％-99.9％ with H1N1 genotype in 2014,98.5％-98.8％ in 2013,and lower than 98.4％ in 2011.Conclusion The popularity of this outbreak was low.Timely isolation of H1 N1 patients and close contacts played an important role in control the epidemics.Implementation of health propaganda and immunization of influenza A/H1N1 should be strengthened.