The clinical efficacy of oral valaciclovir plus intradermal injection of steroid hormone for the treatment of herpes zoster patients
10.3760/cma.j.issn.1003-9279.2015.04.018
- VernacularTitle:激素联合伐昔洛韦治疗带状疱疹疗效观察
- Author:
Jizheng CUI
1
;
Jinwei ZHANG
;
Yun ZHANG
;
Zhengliang MA
Author Information
1. 21002,南京医科大学公共卫生学院
- Keywords:
Herpes zoster;
Valaciclovir;
Intradermal tests;
Hormones;
Neuralgia
- From:
Chinese Journal of Experimental and Clinical Virology
2015;29(4):345-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of oral valaciclovir plus intradermal injection of methylprednisolone for the treatment of herpes zoster patients.Methods Sixty herpes zoster patients were randomly divided into two groups as follow:Group A:30 patients received oral valaciclovir plus intradermal injection of methylprednisolone,and Group B:30 patients treated with oral valaciclovir.And the following indicators,including herpes evaluation index,pain rating index,the incidence of postherpetic neuralgia,and comprehensive therapeutic effect were compared between the two groups after treatment.Results The baseline characteristics were comparable between Group A and B.The time to cessation of new lesion formation,complete rash crusting,cessation of pain and pain intensity after the treatment in Group A were significantly superior to those in group B.And the incidence of postherpetic neuralgia in Group A was significantly lower than that of Group B at 30 days of follow-up.However,no significant difference was found between the two groups at 60 and 90 days of follow-up.Overall,the total clinical effective rate of Group A (86.7 ％) was better than Group B (63.3 ％).Conclusion The treatment of oral valaciclovir plus intradermal injection of methylprednisolone was superior to oral valaciclovir in improving the clinical symptoms of HZ patients and reducing the incidence of postherpetic neuralgia.
