Research on the relationship between HPV and cervical cancer based on molecular evolution methods

VernacularTitle:基于分子进化方法研究HPV与子宫颈癌相互关系
Author: Qian WANG ¹ ; Xing WU ; Xiuli MAO ; Dehong GAO ; Rui YAN
Author Information

1. 202150,上海市崇明县第三人民医院妇产科
Keywords: Cervix neoplasms; Papillomavirus,human; Geneotype; Phylogeny
From: Chinese Journal of Experimental and Clinical Virology 2015;29(4):342-344
CountryChina
Language:Chinese
Abstract: Objective We aimed to analyze the relationship among all types of HPV and cervical cancer and predict potential high-risk HPV based bioinformatics methods.Provide theoretical basis for clinical prevention and early diagnosis for cervical cancer.Methods A total of 131 types HPV gene sequences from GenBank were downloaded.HPV phylogenetic tree were constructed use the MEGA software.Results Current global HPV can be divided into five categories according to complete gene molecular evolution analysis,high-risk types HPV are height together.Further to the mucous membrane affinity types HPV gene analysis shows that the evolution of the E6,E7 gene closer to the distribution of the whole genome evolution tree.We predict the HPV 26,34,53,66,67,97 have potential dangers with cervical cancer.Conclusion Building the HPV data based on the analysis of molecular evolution method of HPV affinity relationship with cervical cancer.Provide theoretical foundations for HPV clinical prevention and treatment of cervical cancer.