Relationship between the levels of IP-10 mRNA in peripheral blood mononuclear cells and prognosis of chronic hepatitis B virus related liver failure
10.3760/cma.j.issn.1003-9279.2015.04.013
- VernacularTitle:PBMC IP-10mRNA对慢性HBV感染相关肝衰竭预后的影响
- Author:
Xiaolin WANG
1
;
Shaojun HUANG
;
Lingxiang XING
;
Xiaoying HAN
;
Xiuzhen WANG
;
Xiuji CHEN
Author Information
1. 湖北文理学院附属襄阳市中心医院消化二科
- Keywords:
Liver failure;
Prognosis;
Leukocytes,mononuclears;
RNA;
Chemotactic factors
- From:
Chinese Journal of Experimental and Clinical Virology
2015;29(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the levels of IP-10 mRNA in peripheral blood mononuclear cells (PBMCs) and prognosis of acute-on-chronic hepatitis B virus related liver failure (HBV-ACLF).Methods Fifty patients diagnosed with HBV-ACLF were administered a combined modality therapy and followed up until death or for 3 months.In addition,20 patients with chronic hepatitis B(CHB),20 patients with hepatitis B related cirrhosis and 20 healthy volunteers were matched for use as control.The levels of IP-10 mRNA in PBMCs were detected at baseline and last follow-up visit and compared between groups by statistical analysis.Results At baseline,the CHB group had a significantly higher level of IP-10 mRNA in PBNCs than the healthy control group(t =-6.972,P ＜0.01).However,the level of IP-10 mRNA in PBMCs of the liver failure group was significantly higher than that of boththe CHB group(t =2.510,P ＜ 0.05) and the healthy control group (t =8.648,P ＜ 0.01).When patients within the liver failure group were divided by survival and death occurring during the 3-month follow-up period,the patients who died were found to have a significantly higher level of IP-10 mRNA in PBMCs than the surviving patients(P ＜ 0.01).The area under the curve of ROC curve is 0.81,and cut off value is 0.9255.Conclusion The level of IP-10 mRNA in PBMCs is positively correlated with risk of death in patients with HBV-ACLF,and its detecting might predict the prognosis of HBV-ACLF.
