Liver histological characteristics of 124 children with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2015.04.011
- VernacularTitle:124例儿童慢性乙型肝炎肝组织病理变化特征分析
- Author:
Qicai LIU
1
;
Siwei LIN
;
Weiping CAI
;
Haolan HE
;
Jiansheng ZHANG
;
Junqing YI
;
Baolin LIAO
Author Information
1. 广州市第八人民医院感染科
- Keywords:
Hepatitis B virus;
Child health services;
Histology,comparative
- From:
Chinese Journal of Experimental and Clinical Virology
2015;29(4):322-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the liver histological characteristics of children with chronic hepatitis B (CHB).Methods We recruited data of children with CHB and liver biopsy,then analyzed their liver histopathological characteristics and their associations with laboratory parameters.Results One hundred and twenty-four children with CHB were included in the present study,including 114 (91.9％) HBeAg-positive CHB children and 10 (8.1％) HBeAg-negative CHB children.In HBeAg-positive CHB children,the frequency of significant necroinflammation stratified by ALT levels was 32.1％ (9/28) in ALT ≤ULN,60.7％ (17/28) in ALT(1-2) ×ULN and 81.0％ (47/58) in ALT＞2 ×ULN group,while significant fibrosis was 46.4％ (13/28) in ALT ≤ ULN,71.4％ (20/28) in ALT (1-2) × ULN and 74.1％ (43/58) in ALT ＞ 2 × ULN group,respectively.Significant liver histological abnormalities were much higher in the ALT ＞ 2 × ULN and ALT (1-2) × ULN groups than the ALT ≤ ULN group.Logistic analysis indicated only AST levels associated with significant inflammation (OR =1.032,P =0.008) and significant fibrosis (OR =1.026,P =0.007).Conclusion Frequencies of significant liver histological abnormalities in children with CHB are high,and AST levels are associated with them.
