The human herpes viruses (HHVs) and B19 infection among children are associated with abnormal liver function of unknown origin
10.3760/cma.j.issn.1003-9279.2015.04.003
- VernacularTitle:不明原因肝功能异常患儿人群血清中HHVs和B19病毒感染的研究
- Author:
Weimin ZHOU
1
;
Xinyi TAN
;
Yamin LI
;
Wenjie TAN
Author Information
1. 中国疾病预防控制中心病毒病预防控制所
- Keywords:
Herpes viridae;
Parvovirus B19,human;
Liver fumction tests;
Polymerase chein reaction
- From:
Chinese Journal of Experimental and Clinical Virology
2015;29(4):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the etiology significance of human herpes viruses (HHV1-7) and human Parvovirus B19 (B19) among children with abnormal liver function of unknown origin(ALUO).Methods Serum samples were randomly collected from 62 patients under 14 years old with ALUO in Beijing.And 123 serum samples from healthy children were collected as the control (normal cohort).The HHV1-7 and B19 infection were detected by multiple PCR and nested PCR,respectively.Results Total 45 samples from the patients group were detected as positive of HHV1-7 or B19 infection.The positive rate (72.58％,45/62) was significantly higher than the control group (52/123,42.28％).Furthermore,four viruses were dominant among pediatric patients with ALUO and significantly higher than the normal cohort,which were Epstein-Barr virus (EBV,12.9％ vs 3.3％),Cytomegalovirus (CMV,33.9％ vs 18.7％),human herpes viruses 6(HHV6,19.4％ vs 5.7％) and B19 (41.9％ vs 26.8％).Conclusions The significant correlation between the human herpes viruses (HHVs) and B19 infection and pediatric patients with ALUO need be considered and paid enough attention in clinic.
