Analysis of genotypes in hepatitis B patients and its clinical significance

VernacularTitle:乙型肝炎病毒基因分型检测及临床意义分析
Author: Youli MA ¹ ; Lifang WANG ; Fuyi XIE ; Aihua SUN
Author Information

1. 315000,宁波市医疗中心李惠利医院输血科
Keywords: Hepatitis B virus; Genotype; Hepatitis B e antigens; DNA
From: Chinese Journal of Experimental and Clinical Virology 2015;29(3):248-250
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship of HBV genotypes and the age of patients,the positive ratio of HBV e antigen (HBeAg),DNA load in serum of patients,and its clinical significance.Methods We tested HBV B and C genotypes in 344 Zhejiang patients with hepatitis B,compared their clinical differences.Enzyme linked immune sorbent assay(ELISA) was used to test the HBeAg;HBV DNA copies was detected by time fluorescence quantitative PCR.Make comprehensive analysis of these indexes.Results Among the 344 Zhejiang HBV patients,113 patients (32.8％),217 patients (63.1％) and 14 patients (4.1％) were infected by HBV genotype genotype B,C and B + C,respectively.Positive ratio of HBeAg and HBV DNA in genotype C were higher than that of genotype B(P ＜0.01).The ratio of high level virus load(HBV DNA ＞ 105 copies/ml) in genotype C patients was higher than that in genotype B patients (P ＜ 0.01).Conclusion Genotype C is the major genotype in Zhejiang province.Genotypes are associated with the age of patients,positive ratio of HBeAg,DNA load in serum of patients.