Treatment of advanced gastric cancer with Xinjia Liangfu Granules combined with chemotherapy
10.3969/j.issn.1006-2157.2017.07.011
- VernacularTitle:新加良附颗粒配合化疗治疗进展期胃癌临床研究
- Author:
Jing WANG
1
;
Shanshan GUO
;
Li HOU
;
Xinyi CHEN
;
Shaodan TIAN
Author Information
1. 北京中医药大学东直门医院 北京100700
- Keywords:
clinical studies;
gastric cancer;
Xinjia Liangfu (Modified Galangal and Cyperus) Granules;
advanced gastric cancer
- From:
Journal of Beijing University of Traditional Chinese Medicine
2017;40(7):593-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Xinjia Liangfu (Modified Galangal and Cyperus) Granules on advanced gastric cancer.Methods The patients with stage Ⅲ/Ⅳ gastric cancer (n =42) were randomly divided into control group and treatment group by applying prospective randomized controlled multi-center clinical trial method.The treatment group was treated with standard chemotherapy regimens combined with Xinjia Liangfu Granules,and control group,with only chemotherapy regimens.During the therapeutic course,2 groups were given the best supportive care and observed for 4 cycles of chemotherapy.The scores of symptoms and signs,Karnofsky performance status (KPS),pain numerical rating scale,tumor size and indexes of blood and urine routine tests,liver and renal functions and electrocardiogram were recorded on the day of grouping and at the end of each cycle of chemotherapy.Results There were 21 cases in treatment group,20 in control group and 1 case was missed.The trial results showed that the relief of symptoms and signs was significant superior in treatment group to that in control group (P ＜ 0.005).The symptoms of stomach pain,abdominal distension and pain,fearing of cold,cold limbs and loss of appetite were relieved in treatment group (P ＜ 0.05).The improvement of total physical condition were superior in treatment group to that in control group (P ＜0.05).The treatment group had higher clinical remission rate compared with control group but the difference had no statistical significance (P ＞ 0.05).Xinjia Liangfu Granules had a higher safety in clinical administration.Conclusion Xinjia Liangfu Granules has the effects of relieving symptoms,improving quality of life and reducing toxic and side effects of chemotherapy,and it is safe and effective in clinic.
