Different human parvovirus B19 subgroup circulation in Tibet and Han population in China

VernacularTitle:西藏藏族人群中细小病毒B19基因与内地汉族人群的差异
Author: Na ZHU ¹ ; Rui TONG ; Weimin ZHOU ; Xinyi TAN ; Yongliang LOU ; Wenjie TAN
Author Information

1. 中国疾病预防控制中心病毒病预防控制所
Keywords: Parvovirus B19,human; Phylgeny
From: Chinese Journal of Experimental and Clinical Virology 2015;29(2):112-114
CountryChina
Language:Chinese
Abstract: Objective To investigate the genetic diversity differences of human parvoviruse B19 and parvovirus 4 (PRVA4) in Tibet and Han population in China.Methods Phylogenetic analysis was performed on genome fragments of B19 or PARV4 obtained from the blood samples of Tibet and Han population in China by using a PCR followed by sequencing.Results Ten partial VP1 fragments of B19 (2 from Tibet,3 from Sichuan,5 from Zhejiang) and 10 partial ORF1 fragments of PAV4 (2 from Tibet,2 from Sichuan,1 Yunnan,5 from Zhejiang) were obtained.Phylogenetic analysis indicated that different B19 subgroup circulates in Tibet and Han population although they belong to the same 1A subtype.While the gene evolution of PAV4 is very conserved between the Tibet and Han population in China.Conclusion These studies on genetic diversity of B19 in different Chinese population provide a way for detection and prevention of B19 human parvovirus infection.