The effect of HPV coinfections on the risk of cervical cancer and precancerosis

VernacularTitle:人乳头状瘤病毒混合感染对高度鳞状上皮内病变和宫颈癌的风险研究
Author: Wei LI ¹ ; Jieqiang LYU ; Yi LU
Author Information

1. 温州医科大学温州市第三临床学院妇产科
Keywords: Papillomavirus,human; Cervical neoplasms; Genes
From: Chinese Journal of Experimental and Clinical Virology 2015;29(1):41-43
CountryChina
Language:Chinese
Abstract: Objective To study the effect of HPV coinfections on the risk of cervical cancer and precancerosis.Methods We randomly selected the female patients which did cervical pathology and not undergo any treatment in recent five years; PCR was used to detect HPV genotyping.Results A total of 755 patients (56.98％) were infected with HPV,154 in negative for intraepithelial lesion or malignancy (37.84％),152 in low-grade squamous intraepithelial lesion (47.64％),270 in high-grade squamous intraepithelial lesion (64.28％) and all of cervical cancer patients were infected (100％) ; HPV16 type is most common,followed by type 18,68 and 58.There were 423 patients with mixed infections,and HPV16 and HPV68 type mixed infections had a synergistic effect,can significantly improved the high-grade intraepithelial neoplasia and cervical cancer incidence.Conclusion HPV mixed infection is closely related to the cervical cancer,and HPV16 and HPV68 type mixed infections can significantly improved cervical cancer and precancerosis incidence.