Central mechanism of analgesic effect of Huaisanzhen on L5 nerve root pain based on functional magnetic resonance imaging
10.3969/j.issn.1006-2157.2017.03.015
- VernacularTitle:基于功能磁共振成像技术研究踝三针对第5腰椎神经根性痛镇痛作用的中枢机制
- Author:
Yijun LIU
1
;
Yong YANG
;
Bin ZHOU
;
Fei SUN
;
Xiaoyan CHEN
;
Youlong ZHOU
Author Information
1. 河南中医药大学第三附属医院 河南 450008
- Keywords:
functional magnetic resonance imaging;
fifth lumbar vertebra;
Huaisanzhen;
pain
- From:
Journal of Beijing University of Traditional Chinese Medicine
2017;40(3):259-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To illuminate the central mechanism of analgesic effect of Huaisanzhen on nerve root pain of the fifth lumbar vertebra (L5) of lumbar disc herniation (LDH) by applying resting functional magnetic resonance imaging (fMRI).Methods The patients (n=10) with L5 nerve root pain of LDH were given the first resting fMRI, then acupuncture in acupoint of Gentong 2 of Huaisanzhen, and finally the second resting fMRI.The obtained test imagines and data were analyzed and processed by using relevant software.Results The brain regions activated by pure resting state included bilateral paracentral lobules, cingulate gyrus, thalamus and occipital lobe, third periventricular zones, optic chiasm, midbrain periaqueductal gray and cerebellar vermis and other parts.The brain regions activated by acupuncture included bilateral occipital lobe, temporal lobe, parietal lobe and left side of the midbrain, and some scattered activation regions in cerebellum.The brain regions activated after acupuncture included bilateral temporal lobe, left thalamus, splenium of corpus callosum, optic chiasm, right internal capsule, pons, midbrain periaqueductal gray and other parts.Conclusion L5 nerve root pain causes the changes of brain function areas, and activities and active levels of resting state default network are inhibited and reduced.After acupuncture in acupoint of Gentong 2, the signals reaches the functional regions of brain through nerve pathways and they were activated or inhibited resulting in analgesic effect.
