Effects of recombinant human brain natriuretic peptide on heart failure in acute severe viral myocarditis patients
10.3760/cma.j.issn.1003-9279.2014.06.023
- VernacularTitle:新活素在重症病毒性心肌炎心力衰竭中的作用
- Author:
Zhenda ZHENG
1
;
Cailian CHENG
;
Ruimin DONG
;
Changlin ZHAO
;
Lin CHEN
;
Xiaoxian QIAN
Author Information
1. 中山大学附属第三医院
- Keywords:
Natriuretic peptide,brain;
Myocarditis;
Heart failure
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(6):467-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and safety of recombinant human brain natriuretic peptide (rhBNP) on heart failure in acute severe viral myocarditis patients(ASVMC).Methods 27 patients from Jan 2010 to Dec 2013 admitted to the Third Affiliated Hospital of Sun Yat-Sen University were divided into two group,rhBNP group 14 patients,control group 13 patients,rhBNP group received rhBNP on the treatment of cedilanid,diuresis,vascular dilation,BNP,cTnI,CK-MB and echocardiography were observed,therapeutic effect of two group were also observed.Results rhBNP decreased BNP [(203.1 ± 39.8) vs.(1185.5 ±48.3) pg/ml],cTnT [(13.5 ±9.8)vs.(24.8 ±13.2) μg/L],CK-MB[(32.9 ±10.7)vs.(195.3 ± 48.2) U/L],improved LVEF [(59.2 ± 9.2) ％ vs.(38.1 ± 8.8) ％] significantly,P ＜ 0.05.Furthermore,the therapeutic effect of rhBNP group were better than control group(P ＜ 0.05),and we didn' t observe obvious side effects in rhBNP group.Conclusion rhBNP is an effective and safe therapeutic measures for heart failure in ASVMC.
