67 cases of chronic hepatitis C treatment process and follow-up serum ALT, viral load and the change of liver fibrosis indexes
10.3760/cma.j.issn.1003-9279.2014.06.020
- VernacularTitle:67例慢性丙型肝炎治疗过程及随访中血清ALT、病毒载量及肝纤维化指标的变化
- Author:
Yucai FANG
1
;
Qiuying WANG
;
Tonggui PAN
;
Yanfei YANG
;
Xiaolei GAO
Author Information
1. 311500,浙江省桐庐县第一人民医院
- Keywords:
Hepatitis C,chronic;
Hepatovirus;
RNA;
Interferon alpha 2 b;
Transaminases;
Liver cirrhosis
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(6):461-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective Observation of polyethylene glycol (peg) interferon alpha 2 b plus ribavirin treatment of chronic hepatitis C liver function,viral replication and liver fibrosis index in the process of change.Methods Detection of 67 cases of chronic hepatitis C patients in the treatment with interferon plus ribavirin end of week (0),(48 weeks) and drug withdrawal 12 weeks (60 weeks) in serum alanine aminotransferase (ALT),hepatitis C virus (HCV) RNA (HCV RNA),hyaluronic acid (HA),a former Ⅲ type collagen peptide (PC Ⅲ),collagen type Ⅳ (Ⅳ-C) and laminin (LN) level. Results Complete response after treatment group (CR-S,43/67) ALT,4 items of HCV RNA and serum fibrosis indexes were significantly decreased (P ＜ 0.05 or P ＜ 0.01),part of the response group (CR-R,13/67) and no answer (NR,11/67) ALT,4 items of HCV RNA and serum fibrosis index change is not obvious,bounce is even higher.Conclusion Polyethylene glycol interferon alpha 2 b plus ribavirin treatment of chronic hepatitis C response,about 65％ of patients completely as the improvement of liver inflammation,viral RNA drops and liver fibrosis index level declined obviously,suggest that interferon plus ribavirin can inhibit HCV RNA replication,regulate the body's immune function,reduce liver inflammation,improve liver function,reduce liver fibrosis.
