Influence of Huazhuo Jiedu Fang on Akt and c-Met expressions in patients with chronic erosive gastritis (syndrome of turbidity-toxin accumulating in the interior)
10.3969/j.issn.1006-2157.2017.03.011
- VernacularTitle:化浊解毒方对慢性糜烂性胃炎浊毒内蕴证患者蛋白激酶B及肝细胞生长因子受体表达的影响
- Author:
Yangang WANG
1
,
2
;
Xuejiao TIAN
;
Jingjing LV
;
Diangui LI
Author Information
1. 河北省中医院 河北 050011
2. 河北医科大学研究生学院
- Keywords:
chronic erosive gastritis;
syndrome of turbidity-toxin accumulating in the interior;
Huazhuo Jiedu Fang;
Akt;
c-Met
- From:
Journal of Beijing University of Traditional Chinese Medicine
2017;40(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Huazhuo Jiedu Fang in patients with chronic erosive gastritis (CEG, syndrome of turbidity-toxin accumulating in the interior), and investigate its effect mechanism based on the expression changes of protein kinase B (Akt) and hepatocyte growth factor receptor (c-Met) in gastric mucous tissue and serum before and after treatment.Methods The patients (n=80) were randomly divided into 2 groups according to the design of randomized single blind controlled clinical trials, and treatment group was treated with Huazhuo Jiedu Fang and control group was treated with Alatan Wuwei Wan.The expression levels of Akt and c-Met in serum and gastric mucous tissue were observed in 2 groups before and after treatment.Results The expression level of Akt decreased significantly in treatment group compared with control group (P<0.05) in serum and gastric mucous tissue, and expression level of c-Met in gastric mucous tissue decreased significantly in treatment group compared with control group (P<0.05).Conclusion Huazhuo Jiedu Fang can reduce significantly expression levels of Akt and c-Met in serum and gastric mucous tissue in patients with chronic erosive gastritis CEG (syndrome of turbidity-toxin accumulating in the interior).The effect mechanism may be that Huazhuo Jiedu Fang can regulate expression levels and activities of Akt and c-Met.
