Clinical significance of detection of HBV pre-S1 antigen
10.3760/cma.j.issn.1003-9279.2014.06.018
- VernacularTitle:检测乙型肝炎病毒前S1抗原的临床价值
- Author:
Jia MAO
1
;
Jinxiu WANG
;
Yan WANG
;
Xia LIU
Author Information
1. 首都医科大学附属北京友谊医院
- Keywords:
Antigens;
Hepaticis B virus;
DNA
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(6):455-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective Through the detection of hepatitis B virus pre-S1 antigen,hepatitis B virus DNA and hepatitis B two pairs of semi (HBV M),to investigate the significance of HBV pre-S1 antigen for clinical diagnosis of hepatitis B.Methods A total of 276 sera samples were tested for hepatitis B virus preS1 antigen and hepatitis B two pairs of semi by ELISA methods for detection,HBV DNA was detected by real-time fluorescence quantitative PCR method.Results The positive rate of serum HBeAg,pre-S1 antigen and HBV DNA were 56.5％,73.9％ and 76％ ;of the 156 HBeAg positive samples,the positive rate of HBV DNA (94.8％) and the positive rate of pre-S1antigen (92.3％),there was no significant difference between the positive rate of HBV DNA and pre-S1antigen; of the 120 HBeAg negative samples without significant difference between the positive rate of HBV DNA and pre-S1antigen; HBV DNA high level group [1.0 × (105-10s) 、1.0 × (103-105)] the positive rate of pre S1 antigen was significantly higher than low level group(＜ 1.0 × 103) Conclusion pre-S1 antigen,HBeAg and HBV DNA had a high coincidence rate,HBeAg negative serum without DNA detection,pre-S1antigen may play a supplementary role to prompt whether the virus replication.
