Myxoma virus on endometrial cancer xenografts in nude mice inhibitory effect and mechanism

VernacularTitle:黏液瘤病毒对裸鼠子宫内膜癌移植瘤的抑瘤作用及机制
Author: Yun ZHOU ¹ ; Keke XU ; Rong GUO ; Min HUANG ; Hongjie SUN
Author Information

1. 518010,深圳市第五人民医院妇产科
Keywords: Endometrial neoplasms; Myxoma virus; Models,animal
From: Chinese Journal of Experimental and Clinical Virology 2014;28(6):440-442
CountryChina
Language:Chinese
Abstract: Objective Explored the effects of Myxoma virus in endometrial cancer of Nude Mouse animal model in vivo.Methods CD-1 Nude mice were randomly divided into three groups with 8 mice eachgroup and established mice models of endometrial carcinoma,and group M was administrated by1 × 107PFU MV(10 μl)QOD,the other 2 group (group D and group B) was administrated by 10μl dead virus and normalsaline,respectively.The time of tumorigenesis,tumorformationrates and the tumor volumes were observed,and theP13K,Akt expression changes in nude mice models of endometrialcarcinoma were assessed by immunohistochemical method.Results The endometrial cancer in all nude mice were established successfully.And tumor growth in group M were significantly decreased than group D and group B after injection,some tumor were lessened,the expression of PI3k,Akt were decreased in group M.Conclusion Administration of MV into mice models of endometrial carcinoma resulted in the reduction of tumor volumes by suppressing tumor angiogenesis and the PI3K/Akt path-way which is related to the tumor cell proliferation.