The Study on relationship between cervical dysplasia and microbial infections with cervical epithelial DNA-Ploidy analysis
10.3760/cma.j.issn.1003-9279.2014.06.011
- VernacularTitle:细胞图像DNA倍体分析结合高危型HPV、支原体和衣原体检查与宫颈上皮内瘤变相关性研究
- Author:
Lidong ZHANG
1
;
Huimin ZHANG
;
Meiling LIU
;
Qingping JIANG
;
Kun NIE
Author Information
1. 广州医科大学附属第三医院妇产科
- Keywords:
DNA;
Papillomavirus,human;
Mycoplasma;
Chlamydia;
Pathology
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(6):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between cervical dysplasia and high risk type of Human Papillomavirus (HR-HPV),Ureaplasma urealyticum/ Mycoplasma hominis (UU/Mh) or Chlamydia Trachomatis (CT) infections with cervical epithelial DNA Ploidy Analysis,so that combining the infection with the result of cervical cancer screening test to evaluate the real risk of cancer or precancerosis to avoid over-diagnosis and over-treatment.Methods Cervical samples from 265 women on child-bearing age were involved in cervical cancer screening with DNA-Ploidy Analysis (DNA-ICM).The women' s samples also be tested by HPV test,UU/Mh test and CT test.The biopsy result is regarded to be the golden standard.Results Among the 285 biopsy results,the chronic cervicitis occupied 179,CIN I 60,CIN Ⅱ 20 CIN Ⅲ 25 and cervical cancer 1.Regression result indicated that DNA-Aneuploid and HR HPV have highest risk to cervical lesion.In the group with infectious factors,the ones with dual-factor infection in CIN Ⅰ is 32.43％ while 56.00％ in CIN Ⅲ as the most.Nevertheless,the most in CIN Ⅱ is HR-HPV as 50.00％,which emerged as 40.00％ in CIN Ⅲ.Conclusion The group with DNA aneuploidy combined with HR-HPV infection or HR-HPV and UU/Mh infection has the high potential risk of malignancy.
