Clinical efficacy of human papillomavirus (HPV) genotyping in screening for cervical disorders
10.3760/cma.j.issn.1003-9279.2014.06.010
- VernacularTitle:人类乳头状瘤病毒分型检测在宫颈癌筛查中的临床研究
- Author:
Rui CHEN
1
;
Jian ZHAO
;
Lirong ZHU
;
Ling YIN
;
Dai ZHANG
;
Xia TAO
;
Hongwu WEN
Author Information
1. 100034,北京大学第一医院妇产科
- Keywords:
Papillomavirus,human;
Genotype;
Cervical intraepithelial neoplasia;
Cervix neoplasms
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(6):429-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of HPV genotyping in diagnosis of cervical lesions.Methods Totally 1715 patients seen in Department of Obstetrics and Gynecology,Peking University First Hospital from January 2010 to December 2012 were chosen to be evaluated.All the patients experienced cervical Liquid-based cytology test,HPV genotyping and multiple punch biopsy during colposcopy and they were confirmed of cervical intraepithelial neoplasia (CIN) through histopathological examination.The clinical efficacy of HPV genotyping was evaluated.Results HPV 16,58,52,33 and 31 were the first five types detected in all of the 1715 patients.The first five types detected in the patients with CIN2 + (including CIN2/CIN3/adenocarcinoma in situ/cervical cancer) were HPV 16,58,33,52 and 31.Logistic regression analysis showed that in the CIN2 + patients who were negative for intraepithelial lesion or malignancy (NILM),those with positive HPV 16,33 and 18 had higher risk of CIN2 +,with the regression coefficient OR 5.031 (P =0.000),2.375 (P =0.000) and 1.598 (P =0.027).The cervical liquid-based cytology showed that there was a higher risk of CIN2 + for atypical squamous cells of undetermined significance (ASCUS) with positive HPV 16 and 18,and the regression coefficients OR were 5.139 (P =0.000) and 2.096 (P =0.025),respectively ; and the low-grade squamous intraepithelial lesion (LSIL) with positive HPV 16,33 and 52 had higher risk of CIN2 +,the regression coefficients OR were 5.774(P =0.000),3.368(P =0.000) and 1.747(P =0.034).Conclusion HPV genotyping is significantly useful for cervical screening.It is an important parameter for directing the clinical treatment in ASCUS and LSIL patients with negative cytology results,especially HPV 16 positive patients need to be further evaluated.
