Hepatic expression of sterol regulatory element binding protein 1c and its significance in patients with non-alcoholic fatty liver disease
10.3760/cma.j.issn.1003-9279.2014.06.005
- VernacularTitle:非酒精性脂肪肝患者肝脏固醇调节元件结合蛋白1c的表达及意义
- Author:
Zhenjiang SUN
1
;
Weizhen SHI
;
Yufang WANG
;
Ping Jun SHI
;
Jianchun GUO
Author Information
1. 310023,杭州市西溪医院
- Keywords:
Proteins;
Liver disease
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(6):413-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hepatic expression of sterol regulatory element binding protein (SREBP)-1c in patients with non-alcoholic fatty liver disease (NAFLD) and its significance.Methods Twenty patients with NAFLD were included,and 20 age/sex matched asymptomatic HBV carriers (ASC) without steatosis evidenced by liver biopsy were used as control in the same time scale.Hepatic SREBP1c was detected using SP method of immunohistochemistry.An automatic biochemical analyzer (Hitachi 7060) was used to measure serum levels of lipids (TG,CHO),fasting blood glucose (FBG) and liver enzymes (AST,A LT,and GGT),and electrochemiluminescence was used to determine fasting insulin (FINS).Results Compared with the control group,NAFLD patients showed diffusely hepatic steatosis and a significantly higher expression of hepatic SREBP1c (P ＜ 0.05).Consistently,serum levels of ALT,AST,TG,CHO,FSG and FINS all increased than those of control group (P ＜ 0.05).Conclusions Hepatic expression of SREBP1c increased significantly in patients with NAFLD,and this over expression may be involve in fatty degeneration of the livers in human.
