Evolution of GⅡ.4 norovirus epitopes of Huzhou City during 2008-2014

VernacularTitle:2008-2014年GⅡ.4诺如病毒抗原表位进化研究
Author: Liping CHEN ¹ ; Jiankang HAN ; Lei JI ; Xiaofang WU ; Deshun XU
Author Information

1. 湖州市疾病预防控制中心
Keywords: Norovirus; Proteins; Antigens
From: Chinese Journal of Experimental and Clinical Virology 2014;28(6):407-409
CountryChina
Language:Chinese
Abstract: Objective To obtain more insight into the genetic and structural bases of the selective advantage of new GGⅡ.4 variants over the old GGⅡ.4 variants.Methods We sequenced the complete capsid of 13 full-length GⅡ.4 norovirus virus VP1 region from 2008 to 2014 and find the key variable sites.Results GⅡ.4 norovirus virus has gone though three big variation during the past seven years.The noroviruses in 2008 and 2009 were the 2006b variant; virus detected in 2010 and 2011 were the 2010 variant ; virus detected in 2012-2014 were the latest 2012 variant.At the amino acid level,we found 77 information sites (540 amino acids in the 14.3％).39 of them located in the P2 region,N-terminal,4; S region,18; P1 region,16.Conclusions GⅡ.4 noroviruses have been recognized as a leading cause of severe viral gastroenteritis worldwide.During the past decades,four worldwide epidemics of acute gastroenteritis caused by emerging variants of GGⅡ.4 noroviruses have been described.Emerging new variant lineages replaced the previously circulating dominant types rapidly and completely.