Fever with thrombocytopenia syndrome patients' serum new Buniavirus IgM antibodies dynamic and its clinical significance
10.3760/cma.j.issn.1003-9279.2014.05.021
- VernacularTitle:发热伴血小板减少综合征患者血清新布尼亚病毒IgM抗体动态变化及其临床意义
- Author:
Jianjing ZHANG
1
;
Shibo LI
;
Zhongfa WANG
;
Yi REN
Author Information
1. 316200,浙江省岱山县人民医院内三科
- Keywords:
Thrombocytopenia;
Buniavirus;
Immunoglobulin M
- From:
Chinese Journal of Experimental and Clinical Virology
2014;28(5):383-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective Learning the dynamic changes of serum new Buniavirus IgM antibody of fever with thrombocytopenia syndrome cases to cover the missing of early diagnosis method for new Buniavirus nucleic acid detecting negative cases,provide the basis for clinical diagnosis and correct treatment.Methods Select the confirmed cases that the first serologic test results for the new Buniavirus nucleic acid testing is positive and negative for IgM antibody test,reserve the consecutive serum samples from patients which is taken every other day until leaving hospital,use Mac-ELISA method to detect the serum specimens of the new Buniavirus IgM seroconversion time and dynamic changes,and calculate the percentage of seroconversion time and the average seroconversion time.Results The new Buniavirus IgM seroconversion time proportions of the serum of the 16 patients who meet the requirements of the study after the onset of disease:5 d:2/16;7 d:6/16;9 d:9/16;11 d:10/16;13 d:12/16;15 d:16/16,and the average seroconversion time is 10.25 ± 3.58 days.Conclusions The serum new Buniavirus IgM antibody of the 16 fever with thrombocytopenia cases can be conversed as early as five days after the onset of disease and the latest with 15 days,then the density of the patient's serum antibody gradually increases after 基金 DOI:10.3760/cma.j.issn.1003-9279.2014.04.00 seroconversion and until 30 days after the disease can still maintain a high level.The convalescent serum IgG antibody titer of the 16 patients is 4 times more than the acute phase.New Buniavirus IgM antibodies detection can be used as an auxiliary method of the early diagnosis of fever with thrombocytopenia syndrome cases.
