Clinical study on Huatan Tiaojing Fang combined with Diane-35 on treat-ment of polycystic ovary syndrome patients with phlegm-dampness ob-struction pattern
10.3969/j.issn.1006-2157.2017.01.015
- VernacularTitle:化痰调经方联合达英－35治疗多囊卵巢综合征痰湿阻滞证的临床研究
- Author:
Ping WANG
1
;
Yu SHAO
;
Hui LIN
;
Huaying CHEN
;
Qun HUANG
Author Information
1. 湖南中医药大学 湖南 410208
- Keywords:
Huatan Tiaojing Fang;
Diane-35;
polycystic ovarian syndrome;
phlegm-dampness obstruc-tion pattern;
clinical study
- From:
Journal of Beijing University of Traditional Chinese Medicine
2017;40(1):77-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect and mechanism of Huatan Tiaojing Fang,a Chinese medi-cine compound formulated by the principle of resolving phlegm and regulating menstruation,combined with Diane-35 on polycystic ovary syndrome (PCOS)patients with phlegm-dampness obstruction pattern. Methods A total 60 patients were randomly divided into the treatment group and the control group (each n =30).The patients of the control group took orally Diane-35,and those of the treatment group took orally Diane-35 with Huatan Tiaojing Fang for consecutive three months.Before and after treatment, TCMsymptom total score and individual symptoms integral,menstruation efficacy,serum sex hormone levels,ovarian volume and basal antral follicle count (AFC)were detected and analyzed.Results The total effective rates were equal,96.7% in the treatment group and of 90.0% in the control group (P >0.05).The individual symptoms integral of the treatment group was superior to those of the control group at the end of three months and three months of withdrawal (P <0.05).After treatment,despite there was no significant difference in serum estradiol (E2 ),testosterone (T),follicle stimulating hormone (FSH)and ovarian volume (P >0.05),the regulation of serum luterinizing hormone (LH)and LH/FSH,reduction of basal AFC of the treatment group were superior to those of the control group (P <0.05).Conclusion The clinical effectiveness of Huatan Tiaojing Fang combined with Diane-35 on treatment of PCOS with phlegm-dampness obstruction pattern has been proved,superior to the effective-ness of Diane-35.The potential mechanism is related to regulating serum LH and LH/FSH.
