Microparticles aggregates of peripheral blood in the unstable angina pec-toris patients with blood stasis pattern

VernacularTitle:冠心病血瘀证患者外周血细胞微粒结合体水平的研究
Author: Qiulei JIA ^{1
,

2} ; Hao MENG ; Yuanhui HU ; Yuguang CHU ; Jingjing SHI
Author Information

1. 中国中医科学院广安门医院心内科北京 100053
2. 北京中医药大学
Keywords: coronary heart disease; blood stasis pattern; microparticle; aggregate
From: Journal of Beijing University of Traditional Chinese Medicine 2017;40(1):59-64
CountryChina
Language:Chinese
Abstract: Objective To observe the relationship between aggregates,including platelet-derived microp-article (PMP)-leukocyte microparticle (LMP),PMP-endothelial microparticle (EMP),and PMP-red cell microparticle (RMP),and severity of coronary heart disease (CHD).Methods All CHD patients were divided into blood stasis pattern group and non blood stasis pattern group.The aggregates of PMP-LMP,PMP-EMP,and PMP-RMP in patients with unstable angina pectoris (UA)were detected and their morphology was observed by using imaging flow cytometry.Then the aggregates level of patients of the two groups were analyzed.Results The expression of PMP,LMP,EMP,RMP,PMP-EMP and PMP-RMP in patients with blood stasis pattern were higher than those of patients without blood stasis pattern (P <0.05),which were positively correlated with blood stasis syndrome(P <0.01).Conclusion It showed that PMP,LMP,EMP,RMP,PMP-EMP and PMP-RMP played an important role in the formation of UA with blood stasis pattern.